Consists chiefly of letters from Harvey Cushing to Frederic Woldenor Schreiber (1897-1959); there is also a small amount of correspondence with patients, a letter and a telegram from Louise Charlotte Eisenhardt (1891-1967) to Schreiber regarding Cushing's failing health and death, and Cushing's notes and sketches from two surgical operations on patient Mary Ellen Martin in 1928 and 1929.